1eqy

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[[Image:1eqy.gif|left|200px]]
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{{Seed}}
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[[Image:1eqy.png|left|200px]]
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{{STRUCTURE_1eqy| PDB=1eqy | SCENE= }}
{{STRUCTURE_1eqy| PDB=1eqy | SCENE= }}
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'''COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1'''
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===COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1===
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==Overview==
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The structure of the segment 1 domain of gelsolin, a protein that fragments actin filaments in cells, is reported in complex with actin. Segment 1 binds monomer using an apolar patch rimmed by hydrogen bonds in a cleft between actin domains. On the actin filament model it binds tangentially, disrupting only those contacts between adjacent subunits in one helical strand. The segment 1 fold is general for all segments of the gelsolin family because the conserved residues form the core of the structure. It also provides a basis for understanding the origin of an amyloidosis caused by a gelsolin variant.
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The line below this paragraph, {{ABSTRACT_PUBMED_8395021}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8395021 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8395021}}
==About this Structure==
==About this Structure==
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[[Category: Actin]]
[[Category: Actin]]
[[Category: Gelsolin]]
[[Category: Gelsolin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:25:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:44:30 2008''

Revision as of 22:44, 30 June 2008

Image:1eqy.png

Template:STRUCTURE 1eqy

COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1

Template:ABSTRACT PUBMED 8395021

About this Structure

1EQY is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structure of gelsolin segment 1-actin complex and the mechanism of filament severing., McLaughlin PJ, Gooch JT, Mannherz HG, Weeds AG, Nature. 1993 Aug 19;364(6439):685-92. PMID:8395021

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