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1esl

From Proteopedia

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[[Image:1esl.gif|left|200px]]
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{{STRUCTURE_1esl| PDB=1esl | SCENE= }}
{{STRUCTURE_1esl| PDB=1esl | SCENE= }}
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'''INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS'''
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===INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS===
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==Overview==
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The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.
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(as it appears on PubMed at http://www.pubmed.gov), where 7509040 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7509040}}
==About this Structure==
==About this Structure==
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[[Category: Graves, B J.]]
[[Category: Graves, B J.]]
[[Category: Cell adhesion protein]]
[[Category: Cell adhesion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:28:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:50:00 2008''

Revision as of 22:50, 30 June 2008

Image:1esl.png

Template:STRUCTURE 1esl

INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS

Template:ABSTRACT PUBMED 7509040

About this Structure

1ESL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains., Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, Presky DH, Familletti PC, Wolitzky BA, Burns DK, Nature. 1994 Feb 10;367(6463):532-8. PMID:7509040

Page seeded by OCA on Tue Jul 1 01:50:00 2008

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