1euj

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{{STRUCTURE_1euj| PDB=1euj | SCENE= }}
{{STRUCTURE_1euj| PDB=1euj | SCENE= }}
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'''A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES'''
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===A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES===
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==Overview==
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Endothelial monocyte-activating polypeptide II (EMAP II) is a novel pro-apoptotic cytokine that shares sequence homology with the C-terminal regions of several tRNA synthetases. Pro-EMAP II, the precursor of EMAP II, is associated with the multi-tRNA synthetase complex and facilitates aminoacylation activity. The structure of human EMAP II, solved at 1.8 A resolution, revealed the oligomer-binding fold for binding different tRNAs and a domain that is structurally homologous to other chemokines. The similar structures to the RNA binding motif of EMAP II was previously observed in the anticodon binding domain of yeast Asp-tRNA synthetase (AspRSSC) and the B2 domain of Thermus thermophilus Phe-tRNA synthetase. The RNA binding pattern of EMAP II is likely to be nonspecific, in contrast to the AspRSSC. The peptide sequence that is responsible for cytokine activity is located, for the most part, in the beta1 strand. It is divided into two regions by a neighboring loop.
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The line below this paragraph, {{ABSTRACT_PUBMED_10852899}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10852899 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10852899}}
==About this Structure==
==About this Structure==
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[[Category: Rna binding motif]]
[[Category: Rna binding motif]]
[[Category: Trna synthetase]]
[[Category: Trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:32:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:00:41 2008''

Revision as of 23:00, 30 June 2008

Image:1euj.png

Template:STRUCTURE 1euj

A NOVEL ANTI-TUMOR CYTOKINE CONTAINS A RNA-BINDING MOTIF PRESENT IN AMINOACYL-TRNA SYNTHETASES

Template:ABSTRACT PUBMED 10852899

About this Structure

1EUJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases., Kim Y, Shin J, Li R, Cheong C, Kim K, Kim S, J Biol Chem. 2000 Sep 1;275(35):27062-8. PMID:10852899

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