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1euv

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{{STRUCTURE_1euv| PDB=1euv | SCENE= }}
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'''X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.'''
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===X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.===
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==Overview==
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Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear processes and cell cycle progression in yeast. The Ulp1 protease catalyzes two essential functions in the SUMO pathway: (1) processing of full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted proteins. Selective reduction of the proteolytic reaction produced a covalent thiohemiacetal transition state complex between a Ulp1 C-terminal fragment and its cellular substrate Smt3, the yeast SUMO homolog. The Ulp1-Smt3 crystal structure and functional testing of elements within the conserved interface elucidate determinants of SUMO recognition, processing, and deconjugation. Genetic analysis guided by the structure further reveals a regulatory element N-terminal to the proteolytic domain that is required for cell growth in yeast.
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(as it appears on PubMed at http://www.pubmed.gov), where 10882122 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10882122}}
==About this Structure==
==About this Structure==
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[[Category: Thiohemiacetal]]
[[Category: Thiohemiacetal]]
[[Category: Ubiquitin-like protease 1]]
[[Category: Ubiquitin-like protease 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:32:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:03:29 2008''

Revision as of 23:03, 30 June 2008

Image:1euv.png

Template:STRUCTURE 1euv

X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.

Template:ABSTRACT PUBMED 10882122

About this Structure

1EUV is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast., Mossessova E, Lima CD, Mol Cell. 2000 May;5(5):865-76. PMID:10882122

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