1ev0

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[[Image:1ev0.jpg|left|200px]]
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{{Seed}}
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[[Image:1ev0.png|left|200px]]
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{{STRUCTURE_1ev0| PDB=1ev0 | SCENE= }}
{{STRUCTURE_1ev0| PDB=1ev0 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN'''
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===SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN===
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==Overview==
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Correct positioning of the division septum in Escherichia coli depends on the coordinated action of the MinC, MinD and MinE proteins. Topological specificity is conferred on the MinCD division inhibitor by MinE, which counters MinCD activity only in the vicinity of the preferred midcell division site. Here we report the structure of the homodimeric topological specificity domain of Escherichia coli MinE and show that it forms a novel alphabeta sandwich. Structure-directed mutagenesis of conserved surface residues has enabled us to identify a spatially restricted site on the surface of the protein that is critical for the topological specificity function of MinE.
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(as it appears on PubMed at http://www.pubmed.gov), where 11062554 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11062554}}
==About this Structure==
==About this Structure==
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1EV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EV0 OCA].
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1EV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EV0 OCA].
==Reference==
==Reference==
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[[Category: Minicell]]
[[Category: Minicell]]
[[Category: Topological specificity]]
[[Category: Topological specificity]]
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Revision as of 23:03, 30 June 2008

Template:STRUCTURE 1ev0

SOLUTION STRUCTURE OF THE MINE TOPOLOGICAL SPECIFICITY DOMAIN

Template:ABSTRACT PUBMED 11062554

About this Structure

1EV0 is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Structural basis for the topological specificity function of MinE., King GF, Shih YL, Maciejewski MW, Bains NP, Pan B, Rowland SL, Mullen GP, Rothfield LI, Nat Struct Biol. 2000 Nov;7(11):1013-7. PMID:11062554

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