This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1evm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1evm.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1evm.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1evm| PDB=1evm | SCENE= }}
{{STRUCTURE_1evm| PDB=1evm | SCENE= }}
-
'''NMR OBSERVATION OF A-TETRAD'''
+
===NMR OBSERVATION OF A-TETRAD===
-
==Overview==
+
<!--
-
The structure of the telomeric DNA has been a subject of extensive investigation in recent years due to the realization that it has important functional roles to play in vivo and the observations that truncated telomeric sequences exhibit a great variety of 3D structures in aqueous solutions. In this context, we describe here NMR structural studies on two truncated human telomeric DNA sequences, d-AG(3)T and d-TAG(3)T in solutions containing K(+)ions. The G(3)stretches in both the oligonucleotides were seen to form parallel-stranded quadruplexes. However, the AG(3)segment as a whole, had different structural characteristics. The structure of d-AG(3)T revealed the formation of a novel A-tetrad, which was not seen in d-TAG(3)T. The A's in the tetrad had syn glycosidic conformation as opposed to the anti conformation of the G's in the G-tetrads. The A-tetrad stacked well over the adjacent G-tetrad and the twist angle at this step was smaller in d-AG(3)T than in d-TAG(3)T. These observations are expected to be significant from the point of view of structural diversity and recognition in telomeres.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10481022}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10481022 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10481022}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVM OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVM OCA].
==Reference==
==Reference==
Line 27: Line 31:
[[Category: Human telomere]]
[[Category: Human telomere]]
[[Category: Nmr structure]]
[[Category: Nmr structure]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:34:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:05:24 2008''

Revision as of 23:05, 30 June 2008

Image:1evm.png

Template:STRUCTURE 1evm

NMR OBSERVATION OF A-TETRAD

Template:ABSTRACT PUBMED 10481022

About this Structure

Full experimental information is available from OCA.

Reference

NMR studies on truncated sequences of human telomeric DNA: observation of a novel A-tetrad., Patel PK, Koti AS, Hosur RV, Nucleic Acids Res. 1999 Oct 1;27(19):3836-43. PMID:10481022

Page seeded by OCA on Tue Jul 1 02:05:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1evm"
Personal tools