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1ewq

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[[Image:1ewq.gif|left|200px]]
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{{STRUCTURE_1ewq| PDB=1ewq | SCENE= }}
{{STRUCTURE_1ewq| PDB=1ewq | SCENE= }}
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'''CRYSTAL STRUCTURE TAQ MUTS COMPLEXED WITH A HETERODUPLEX DNA AT 2.2 A RESOLUTION'''
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===CRYSTAL STRUCTURE TAQ MUTS COMPLEXED WITH A HETERODUPLEX DNA AT 2.2 A RESOLUTION===
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==Overview==
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DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes mispaired and unpaired bases in duplex DNA and initiates mismatch repair. Mutations in human MutS genes cause a predisposition to hereditary nonpolyposis colorectal cancer as well as sporadic tumours. Here we report the crystal structures of a MutS protein and a complex of MutS with a heteroduplex DNA containing an unpaired base. The structures reveal the general architecture of members of the MutS family, an induced-fit mechanism of recognition between four domains of a MutS dimer and a heteroduplex kinked at the mismatch, a composite ATPase active site composed of residues from both MutS subunits, and a transmitter region connecting the mismatch-binding and ATPase domains. The crystal structures also provide a molecular framework for understanding hereditary nonpolyposis colorectal cancer mutations and for postulating testable roles of MutS.
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(as it appears on PubMed at http://www.pubmed.gov), where 11048710 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11048710}}
==About this Structure==
==About this Structure==
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[[Category: Multiple domains of protein]]
[[Category: Multiple domains of protein]]
[[Category: One domain is entirely helical]]
[[Category: One domain is entirely helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:36:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:08:05 2008''

Revision as of 23:08, 30 June 2008

Image:1ewq.png

Template:STRUCTURE 1ewq

CRYSTAL STRUCTURE TAQ MUTS COMPLEXED WITH A HETERODUPLEX DNA AT 2.2 A RESOLUTION

Template:ABSTRACT PUBMED 11048710

About this Structure

1EWQ is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA., Obmolova G, Ban C, Hsieh P, Yang W, Nature. 2000 Oct 12;407(6805):703-10. PMID:11048710

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