1ews

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[[Image:1ews.gif|left|200px]]
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{{Seed}}
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[[Image:1ews.png|left|200px]]
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{{STRUCTURE_1ews| PDB=1ews | SCENE= }}
{{STRUCTURE_1ews| PDB=1ews | SCENE= }}
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'''THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE RABBIT KIDNEY DEFENSIN, RK-1'''
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===THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE RABBIT KIDNEY DEFENSIN, RK-1===
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==Overview==
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NMR spectroscopy and simulated annealing calculations have been used to determine the three-dimensional structure of RK-1, an antimicrobial peptide from rabbit kidney recently discovered from homology screening based on the distinctive physicochemical properties of the corticostatins/defensins. RK-1 consists of 32 residues, including six cysteines arranged into three disulfide bonds. It exhibits antimicrobial activity against Escherichia coli and activates Ca(2+) channels in vitro. Through its physicochemical similarity, identical cysteine spacing, and linkage to the corticostatins/defensins, it was presumed to be a member of this family. However, RK-1 lacks both a large number of arginines in the primary sequence and a high overall positive charge, which are characteristic of this family of peptides. The three-dimensional solution structure, determined by NMR, consists of a triple-stranded antiparallel beta-sheet and a series of turns and is similar to the known structures of other alpha-defensins. This has enabled the definitive classification of RK-1 as a member of this family of antimicrobial peptides. Ultracentrifuge measurements confirmed that like rabbit neutrophil defensins, RK-1 is monomeric in solution, in contrast to human neutrophil defensins, which are dimeric.
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The line below this paragraph, {{ABSTRACT_PUBMED_11123900}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11123900 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11123900}}
==About this Structure==
==About this Structure==
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1EWS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWS OCA].
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1EWS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWS OCA].
==Reference==
==Reference==
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[[Category: Alpha defensin]]
[[Category: Alpha defensin]]
[[Category: Triple-stranded beta-sheet]]
[[Category: Triple-stranded beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:36:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:08:18 2008''

Revision as of 23:08, 30 June 2008

Image:1ews.png

Template:STRUCTURE 1ews

THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE RABBIT KIDNEY DEFENSIN, RK-1

Template:ABSTRACT PUBMED 11123900

About this Structure

1EWS is a Single protein structure of sequence from Oryctolagus cuniculus. Full experimental information is available from OCA.

Reference

Three-dimensional structure of RK-1: a novel alpha-defensin peptide., McManus AM, Dawson NF, Wade JD, Carrington LE, Winzor DJ, Craik DJ, Biochemistry. 2000 Dec 26;39(51):15757-64. PMID:11123900

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