1fiv
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(New page: 200px<br /><applet load="1fiv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fiv, resolution 2.0Å" /> '''STRUCTURE OF AN INHIB...)
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Revision as of 12:50, 20 November 2007
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STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS
Overview
The crystal structure of a recombinant form of the proteinase encoded by, the feline immunodeficiency virus (FIV PR) has been solved at 2 A, resolution and refined to an R-factor of 0.148. The refined structure, includes a peptidomimetic, statine-based inhibitor, LP-149, which is an, even more potent inhibitor of HIV PR. Kinetic parameters were obtained for, the cleavage of five substrates by FIV PR, and inhibition constants were, measured for four inhibitors. The structure of FIV PR resembles other, related retroviral enzymes although few inhibitors of HIV PR are capable, of inhibiting FIV PR. The structure of FIV PR will enhance our knowledge, of this class of enzymes, and will direct testing of new proteinase, inhibitors in a feline animal model.
About this Structure
1FIV is a Single protein structure of sequence from Feline immunodeficiency virus with ACE, NH2 and NPY as ligands. Active as HIV-1 retropepsin, with EC number 3.4.23.16 Full crystallographic information is available from OCA.
Reference
Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus., Wlodawer A, Gustchina A, Reshetnikova L, Lubkowski J, Zdanov A, Hui KY, Angleton EL, Farmerie WG, Goodenow MM, Bhatt D, et al., Nat Struct Biol. 1995 Jun;2(6):480-8. PMID:7664111
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