1ez3

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{{STRUCTURE_1ez3| PDB=1ez3 | SCENE= }}
{{STRUCTURE_1ez3| PDB=1ez3 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE NEURONAL T-SNARE SYNTAXIN-1A'''
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===CRYSTAL STRUCTURE OF THE NEURONAL T-SNARE SYNTAXIN-1A===
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==Overview==
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Intracellular trafficking depends on the docking and fusion of transport vesicles with cellular membranes. Central to docking and fusion is the pairing of SNARE proteins (soluble NSF attachment protein receptors) associated with the vesicle and target membranes (v- and t-SNAREs, respectively). Here, the X-ray structure of an N-terminal conserved domain of the neuronal t-SNARE syntaxin-1A was determined to a resolution of 1.9 A using multiwavelength anomalous diffraction. This X-ray structure, which is in general agreement with an NMR structure of a similar fragment, provides new insight into the interaction surface between the N-terminal domain and the remainder of the protein. In vitro characterization of the intact cytoplasmic domain of syntaxin revealed that it forms dimers, and probably tetramers, at low micromolar concentrations, with concomitant structural changes that can be detected by limited proteolysis. These observations suggest that the promiscuity characteristic of pairing between v-SNAREs and t-SNAREs extends to the formation of homo-oligomeric t-SNARE complexes as well. They also suggest a potential role for the neuronal Sec1 protein (nSec1) in preventing the formation of syntaxin multimers.
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{{ABSTRACT_PUBMED_10913252}}
==About this Structure==
==About this Structure==
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[[Category: Robblee, J.]]
[[Category: Robblee, J.]]
[[Category: Three helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:41:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:14:27 2008''

Revision as of 23:14, 30 June 2008

Image:1ez3.png

Template:STRUCTURE 1ez3

CRYSTAL STRUCTURE OF THE NEURONAL T-SNARE SYNTAXIN-1A

Template:ABSTRACT PUBMED 10913252

About this Structure

1EZ3 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural analysis of the neuronal SNARE protein syntaxin-1A., Lerman JC, Robblee J, Fairman R, Hughson FM, Biochemistry. 2000 Jul 25;39(29):8470-9. PMID:10913252

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