1ez4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ez4.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ez4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ez4| PDB=1ez4 | SCENE= }}
{{STRUCTURE_1ez4| PDB=1ez4 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF NON-ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS PENTOSUS AT 2.3 ANGSTROM RESOLUTION'''
+
===CRYSTAL STRUCTURE OF NON-ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS PENTOSUS AT 2.3 ANGSTROM RESOLUTION===
-
==Overview==
+
<!--
-
L-Lactate dehydrogenase (LDH) from Lactobacillus pentosus is a non-allosteric enzyme, which shows, however, high sequence similarity to allosteric LDHs from certain bacteria. To elucidate the structural basis of the absence of allostery of L. pentosus LDH (LPLDH), we determined the crystal structure of LPLDH at 2.3 A resolution. Bacterial LDHs are tetrameric enzymes composed of identical subunits and exhibit 222 symmetry. The quaternary structure of LPLDH was similar to the active conformation of allosteric LDHs. Structural analysis revealed that the subunit interfaces of LPLDH are optimized mainly through hydrophilic interactions rather than hydrophobic interactions, compared with other LDHs. The subunit interfaces of LPLDH are more specifically stabilized by increased numbers of intersubunit salt bridges and hydrogen bonds, and higher geometrical complementarity. Such high specificity at the subunit interfaces should hinder the rearrangement of the quaternary structure needed for allosteric regulation and thus explain the "non-allostery" of LPLDH.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11807949}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11807949 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11807949}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Wakagi, T.]]
[[Category: Wakagi, T.]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:41:44 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:14:28 2008''

Revision as of 23:14, 30 June 2008

Image:1ez4.png

Template:STRUCTURE 1ez4

CRYSTAL STRUCTURE OF NON-ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS PENTOSUS AT 2.3 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 11807949

About this Structure

1EZ4 is a Single protein structure of sequence from Lactobacillus pentosus. Full crystallographic information is available from OCA.

Reference

Crystal structure of non-allosteric L-lactate dehydrogenase from Lactobacillus pentosus at 2.3 A resolution: specific interactions at subunit interfaces., Uchikoba H, Fushinobu S, Wakagi T, Konno M, Taguchi H, Matsuzawa H, Proteins. 2002 Feb 1;46(2):206-14. PMID:11807949

Page seeded by OCA on Tue Jul 1 02:14:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ez4"
Personal tools