1f08

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{{STRUCTURE_1f08| PDB=1f08 | SCENE= }}
{{STRUCTURE_1f08| PDB=1f08 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS'''
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===CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS===
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==Overview==
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Papillomaviral infection causes both benign and malignant lesions and is a necessary cause of cervical carcinoma. Replication of this virus requires the replication initiation proteins E1 and E2, which bind cooperatively at the origin of replication (ori) as an (E1)2-(E2)2-DNA complex. This is a precursor to larger E1 complexes that distort and unwind the ori. We present the crystal structure of the E1 DNA binding domain refined to 1.9 A resolution. Residues critical for DNA binding are located on an extended loop and an alpha helix. We identify the E1 dimerization surface by selective mutations at an E1/E1 interface observed in the crystal and propose a model for the (E1)2-DNA complex. These and other observations suggest how the E1 DNA binding domain orchestrates assembly of the hexameric helicase on the ori.
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(as it appears on PubMed at http://www.pubmed.gov), where 10949036 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10949036}}
==About this Structure==
==About this Structure==
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[[Category: Papillomavirus]]
[[Category: Papillomavirus]]
[[Category: Replication]]
[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:44:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:17:25 2008''

Revision as of 23:17, 30 June 2008

Image:1f08.png

Template:STRUCTURE 1f08

CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS

Template:ABSTRACT PUBMED 10949036

About this Structure

1F08 is a Single protein structure of sequence from Bovine papillomavirus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus., Enemark EJ, Chen G, Vaughn DE, Stenlund A, Joshua-Tor L, Mol Cell. 2000 Jul;6(1):149-58. PMID:10949036

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