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1f0v

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[[Image:1f0v.gif|left|200px]]
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{{STRUCTURE_1f0v| PDB=1f0v | SCENE= }}
{{STRUCTURE_1f0v| PDB=1f0v | SCENE= }}
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'''Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping'''
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===Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping===
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==Overview==
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Bovine pancreatic ribonuclease (RNase A) forms two types of dimers (a major and a minor component) upon concentration in mild acid. These two dimers exhibit different biophysical and biochemical properties. Earlier we reported that the minor dimer forms by swapping its N-terminal alpha-helix with that of an identical molecule. Here we find that the major dimer forms by swapping its C-terminal beta-strand, thus revealing the first example of three-dimensional (3D) domain swapping taking place in different parts of the same protein. This feature permits RNase A to form tightly bonded higher oligomers. The hinge loop of the major dimer, connecting the swapped beta-strand to the protein core, resembles a short segment of the polar zipper proposed by Perutz and suggests a model for aggregate formation by 3D domain swapping with a polar zipper.
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(as it appears on PubMed at http://www.pubmed.gov), where 11224563 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11224563}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:52:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:18:58 2008''

Revision as of 23:18, 30 June 2008

Image:1f0v.png

Template:STRUCTURE 1f0v

Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping

Template:ABSTRACT PUBMED 11224563

About this Structure

1F0V is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

A domain-swapped RNase A dimer with implications for amyloid formation., Liu Y, Gotte G, Libonati M, Eisenberg D, Nat Struct Biol. 2001 Mar;8(3):211-4. PMID:11224563

Page seeded by OCA on Tue Jul 1 02:18:58 2008

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