1f11

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{{STRUCTURE_1f11| PDB=1f11 | SCENE= }}
{{STRUCTURE_1f11| PDB=1f11 | SCENE= }}
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'''F124 FAB FRAGMENT FROM A MONOCLONAL ANTI-PRES2 ANTIBODY'''
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===F124 FAB FRAGMENT FROM A MONOCLONAL ANTI-PRES2 ANTIBODY===
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==Overview==
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The crystal structure of the Fab fragment from the monoclonal anti-preS2 antibody F124 (IgG1,kappa) has been solved by molecular replacement and refined at 3.0 A resolution. The Fab crystallizes with two independent molecules in the asymmetric unit. F124 recognizes an epitope contained within the preS2 segment between residues 120 and 132 of the surface antigen of hepatitis B virus. The antibody shows a high affinity for the glycan N-linked to Asn123, but it also cross-reacts with the non-glycosylated peptide fragment 120-132. Although crystallization was performed in the presence of an eightfold excess of the cross-reactive peptide, no evidence for the ligand was found in the antigen-binding site, which is close to a neighbouring molecule in the crystal lattice. The antigen-binding site has a groove-like topology which is modulated with pocket-like cavities. It is characterized by a large number of tyrosine and aspartate residues. The importance of germ-line mutations at the binding site is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 10944330 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10944330}}
==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Pres2]]
[[Category: Pres2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:45:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:19:25 2008''

Revision as of 23:19, 30 June 2008

Image:1f11.png

Template:STRUCTURE 1f11

F124 FAB FRAGMENT FROM A MONOCLONAL ANTI-PRES2 ANTIBODY

Template:ABSTRACT PUBMED 10944330

About this Structure

1F11 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the Fab fragment from F124, a monoclonal antibody specific for hepatitis B surface antigen., Saul FA, Vulliez-Le Normand B, Passafiume M, Riottot MM, Bentley GA, Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):945-51. PMID:10944330

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