1f2r

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[[Image:1f2r.gif|left|200px]]
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{{STRUCTURE_1f2r| PDB=1f2r | SCENE= }}
{{STRUCTURE_1f2r| PDB=1f2r | SCENE= }}
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'''NMR STRUCTURE OF THE HETERODIMERIC COMPLEX BETWEEN CAD DOMAINS OF CAD AND ICAD'''
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===NMR STRUCTURE OF THE HETERODIMERIC COMPLEX BETWEEN CAD DOMAINS OF CAD AND ICAD===
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==Overview==
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We present here the structure of the complex between the CAD domain of caspase activated deoxyribonuclease (CAD) and the CAD domain of its inhibitor (ICAD), determined by nuclear magnetic resonance spectroscopy. The two domains adopt a very similar fold, which consists of an alpha-helix and a beta-sheet, and are aligned side by side in the complex. Notably, the positive charges on the strand beta2 at one end of the beta-sheet of CAD and negative charges around the opposite end of the beta-sheet of ICAD are paired in the complex. Point mutations of the charged amino acids at this interface, on either CAD or ICAD, prevented formation of the functional CAD-ICAD complex. This implies that the interaction between the CAD domains of CAD and ICAD is an essential step in the correct folding of CAD in the complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 10932250 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10932250}}
==About this Structure==
==About this Structure==
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1F2R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2R OCA].
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1F2R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2R OCA].
==Reference==
==Reference==
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[[Category: Alpha-beta roll]]
[[Category: Alpha-beta roll]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:49:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:26:38 2008''

Revision as of 23:26, 30 June 2008

Image:1f2r.png

Template:STRUCTURE 1f2r

NMR STRUCTURE OF THE HETERODIMERIC COMPLEX BETWEEN CAD DOMAINS OF CAD AND ICAD

Template:ABSTRACT PUBMED 10932250

About this Structure

1F2R is a Protein complex structure of sequences from Mus musculus. Full experimental information is available from OCA.

Reference

Structure of the heterodimeric complex between CAD domains of CAD and ICAD., Otomo T, Sakahira H, Uegaki K, Nagata S, Yamazaki T, Nat Struct Biol. 2000 Aug;7(8):658-62. PMID:10932250

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