This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1f32

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1f32.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1f32.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1f32| PDB=1f32 | SCENE= }}
{{STRUCTURE_1f32| PDB=1f32 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3'''
+
===CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3===
-
==Overview==
+
<!--
-
The three-dimensional structures of pepsin inhibitor-3 (PI-3) from Ascaris suum and of the complex between PI-3 and porcine pepsin at 1. 75 A and 2.45 A resolution, respectively, have revealed the mechanism of aspartic protease inhibition by this unique inhibitor. PI-3 has a new fold consisting of two domains, each comprising an antiparallel beta-sheet flanked by an alpha-helix. In the enzyme-inhibitor complex, the N-terminal beta-strand of PI-3 pairs with one strand of the 'active site flap' (residues 70-82) of pepsin, thus forming an eight-stranded beta-sheet that spans the two proteins. PI-3 has a novel mode of inhibition, using its N-terminal residues to occupy and therefore block the first three binding pockets in pepsin for substrate residues C-terminal to the scissile bond (S1'-S3'). The molecular structure of the pepsin-PI-3 complex suggests new avenues for the rational design of proteinaceous aspartic proteinase inhibitors.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10932249}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10932249 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10932249}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Petersen, J F.]]
[[Category: Petersen, J F.]]
[[Category: Proteinase inhibitor]]
[[Category: Proteinase inhibitor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:49:59 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:32:10 2008''

Revision as of 23:32, 30 June 2008

Image:1f32.png

Template:STRUCTURE 1f32

CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3

Template:ABSTRACT PUBMED 10932249

About this Structure

1F32 is a Single protein structure of sequence from Ascaris suum. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3., Ng KK, Petersen JF, Cherney MM, Garen C, Zalatoris JJ, Rao-Naik C, Dunn BM, Martzen MR, Peanasky RJ, James MN, Nat Struct Biol. 2000 Aug;7(8):653-7. PMID:10932249

Page seeded by OCA on Tue Jul 1 02:32:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f32"
Personal tools