1f34

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{{STRUCTURE_1f34| PDB=1f34 | SCENE= }}
{{STRUCTURE_1f34| PDB=1f34 | SCENE= }}
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'''CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN'''
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===CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN===
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==Overview==
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The three-dimensional structures of pepsin inhibitor-3 (PI-3) from Ascaris suum and of the complex between PI-3 and porcine pepsin at 1. 75 A and 2.45 A resolution, respectively, have revealed the mechanism of aspartic protease inhibition by this unique inhibitor. PI-3 has a new fold consisting of two domains, each comprising an antiparallel beta-sheet flanked by an alpha-helix. In the enzyme-inhibitor complex, the N-terminal beta-strand of PI-3 pairs with one strand of the 'active site flap' (residues 70-82) of pepsin, thus forming an eight-stranded beta-sheet that spans the two proteins. PI-3 has a novel mode of inhibition, using its N-terminal residues to occupy and therefore block the first three binding pockets in pepsin for substrate residues C-terminal to the scissile bond (S1'-S3'). The molecular structure of the pepsin-PI-3 complex suggests new avenues for the rational design of proteinaceous aspartic proteinase inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 10932249 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10932249}}
==About this Structure==
==About this Structure==
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[[Category: Petersen, J F.]]
[[Category: Petersen, J F.]]
[[Category: Proteinase-inhibitor complex]]
[[Category: Proteinase-inhibitor complex]]
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Revision as of 23:34, 30 June 2008

Image:1f34.png

Template:STRUCTURE 1f34

CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3 BOUND TO PORCINE PEPSIN

Template:ABSTRACT PUBMED 10932249

About this Structure

1F34 is a Protein complex structure of sequences from Ascaris suum and Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3., Ng KK, Petersen JF, Cherney MM, Garen C, Zalatoris JJ, Rao-Naik C, Dunn BM, Martzen MR, Peanasky RJ, James MN, Nat Struct Biol. 2000 Aug;7(8):653-7. PMID:10932249

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