1f3c

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{{STRUCTURE_1f3c| PDB=1f3c | SCENE= }}
{{STRUCTURE_1f3c| PDB=1f3c | SCENE= }}
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'''REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)'''
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===REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)===
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==Overview==
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Dyneins are multi-subunit molecular motors that translocate molecular cargoes along microtubules. Other than acting as an essential component of the dynein motor complex, the 89-residue subunit of dynein light chain (DLC8) also regulates a number of other biological events by binding to various proteins and enzymes. Currently known DLC8 targets include neuronal nitric oxide synthase; the proapoptotic Bcl-2 family member protein designated Bim; a Drosophila RNA localization protein Swallow, myosin V, neuronal scaffolding protein GKAP, and IkappaBalpha, an inhibitor of the NFkappaB transcription factor. The DLC8-binding domains of the various targets are confined within a short, continuous stretch of amino acid residues. However, these domains do not share any obvious sequence homology with each other. Here, the three-dimensional structures of DLC8 complexed with two peptides corresponding to the DLC8-binding domains of neuronal nitric oxide synthase and Bim, respectively, were determined by NMR spectroscopy. Although the two DLC8-binding peptides have entirely different amino acid sequences, both peptides bind to the protein with a remarkable similar conformation by engaging the symmetric DLC8 dimer through antiparallel beta-sheet augmentation via the beta2 strand of the protein. Structural comparison indicates that the two target peptides use different regions within the conformational flexible peptide-binding channels to achieve binding specificity. We have also re-determined the apo-form solution structure of DLC8 in this work. The structures of the DLC8/target peptide complexes, together with the dynamic properties of the protein, provide a molecular basis of DLC8's diverse amino acid sequence-dependent target recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 11178896 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11178896}}
==About this Structure==
==About this Structure==
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1F3C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bkq 1bkq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3C OCA].
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1F3C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1bkq 1bkq]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F3C OCA].
==Reference==
==Reference==
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[[Category: Light chain]]
[[Category: Light chain]]
[[Category: Microtubule]]
[[Category: Microtubule]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:50:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:36:04 2008''

Revision as of 23:36, 30 June 2008

Image:1f3c.png

Template:STRUCTURE 1f3c

REFINED SOLUTION STRUCTURE OF 8KDA DYNEIN LIGHT CHAIN (DLC8)

Template:ABSTRACT PUBMED 11178896

About this Structure

1F3C is a Single protein structure of sequence from Rattus norvegicus. This structure supersedes the now removed PDB entry 1bkq. Full experimental information is available from OCA.

Reference

Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain., Fan J, Zhang Q, Tochio H, Li M, Zhang M, J Mol Biol. 2001 Feb 9;306(1):97-108. PMID:11178896

Page seeded by OCA on Tue Jul 1 02:36:04 2008

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