1f3j

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[[Image:1f3j.jpg|left|200px]]
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{{STRUCTURE_1f3j| PDB=1f3j | SCENE= }}
{{STRUCTURE_1f3j| PDB=1f3j | SCENE= }}
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'''HISTOCOMPATIBILITY ANTIGEN I-AG7'''
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===HISTOCOMPATIBILITY ANTIGEN I-AG7===
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==Overview==
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We have determined the crystal structure of I-Ag7, an integral component in murine type I diabetes development. Several features distinguish I-Ag7 from other non-autoimmune-associated MHC class II molecules, including novel peptide and heterodimer pairing interactions. The binding groove of I-Ag7 is unusual at both terminal ends, with a potentially solvent-exposed channel at the base of the P1 pocket and a widened entrance to the P9 pocket. Peptide binding studies with variants of the hen egg lysozyme I-Ag7 epitope HEL(11-25) support a comprehensive structure-based I-Ag7 binding motif. Residues critical for T cell recognition were investigated with a panel of HEL(11-25)-restricted clones, which uncovered P1 anchor-dependent structural variations. These results establish a framework for future experiments directed at understanding the role of I-Ag7 in autoimmunity.
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(as it appears on PubMed at http://www.pubmed.gov), where 10894169 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10894169}}
==About this Structure==
==About this Structure==
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[[Category: Mhc]]
[[Category: Mhc]]
[[Category: Peptide complex]]
[[Category: Peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:51:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:37:00 2008''

Revision as of 23:37, 30 June 2008

Image:1f3j.png

Template:STRUCTURE 1f3j

HISTOCOMPATIBILITY ANTIGEN I-AG7

Template:ABSTRACT PUBMED 10894169

About this Structure

1F3J is a Protein complex structure of sequences from Gallus gallus and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice., Latek RR, Suri A, Petzold SJ, Nelson CA, Kanagawa O, Unanue ER, Fremont DH, Immunity. 2000 Jun;12(6):699-710. PMID:10894169

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