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1f41

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[[Image:1f41.gif|left|200px]]
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[[Image:1f41.png|left|200px]]
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{{STRUCTURE_1f41| PDB=1f41 | SCENE= }}
{{STRUCTURE_1f41| PDB=1f41 | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN AT 1.5A RESOLUTION'''
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===CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN AT 1.5A RESOLUTION===
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==Overview==
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Self-assembly of the human plasma protein transthyretin (TTR) into unbranched insoluble amyloid fibrils occurs as a result of point mutations that destabilize the molecule, leading to conformational changes. The tertiary structure of native soluble TTR and many of its disease-causing mutants have been determined. Several independent studies by X-ray crystallography have suggested structural differences between TTR variants which are claimed to be of significance for amyloid formation. As these changes are minor and not consistent between the studies, we have compared all TTR structures available at the protein data bank including three wild-types, three non-amyloidogenic mutants, seven amyloidogenic mutants and nine complexes. The reference for this study is a new 1.5 A resolution structure of human wild-type TTR refined to an R-factor/R-free of 18.6 %/21.6 %. The present findings are discussed in the light of the previous structural studies of TTR variants, and show the reported structural differences to be non-significant.
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The line below this paragraph, {{ABSTRACT_PUBMED_10986125}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10986125 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10986125}}
==About this Structure==
==About this Structure==
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[[Category: Sauer-Eriksson, A E.]]
[[Category: Sauer-Eriksson, A E.]]
[[Category: Greek key beta barrel]]
[[Category: Greek key beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:52:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:39:09 2008''

Revision as of 23:39, 30 June 2008

Image:1f41.png

Template:STRUCTURE 1f41

CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN AT 1.5A RESOLUTION

Template:ABSTRACT PUBMED 10986125

About this Structure

1F41 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A comparative analysis of 23 structures of the amyloidogenic protein transthyretin., Hornberg A, Eneqvist T, Olofsson A, Lundgren E, Sauer-Eriksson AE, J Mol Biol. 2000 Sep 22;302(3):649-69. PMID:10986125

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