1fl2
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(New page: 200px<br /><applet load="1fl2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fl2, resolution 1.90Å" /> '''CATALYTIC CORE COMPO...)
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Revision as of 12:53, 20 November 2007
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CATALYTIC CORE COMPONENT OF THE ALKYLHYDROPEROXIDE REDUCTASE AHPF FROM E.COLI
Overview
Alkylhydroperoxide reductases (AhpR, EC 1.6.4.*) are essential for the, oxygen tolerance of aerobic organisms by converting otherwise toxic, hydroperoxides of lipids or nucleic acids to the corresponding alcohols., The AhpF component belongs to the family of pyridine nucleotide-disulphide, oxidoreductases and channels electrons from NAD(P)H towards the AhpC, component which finally reduces cognate substrates. The structure of the, catalytic core of the Escherichia coli AhpF (A212-A521) with a bound FAD, cofactor was determined at 1.9 A resolution in its oxidized state. The, dimeric arrangement of the AhpF catalytic core and the predicted, interaction mode between the N-terminal PDO-like domain and the NADPH, domain favours an intramolecular electron transfer between the two, redox-active disulphide centres of AhpF.
About this Structure
1FL2 is a Single protein structure of sequence from Escherichia coli with SO4 and FAD as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic core component of the alkylhydroperoxide reductase AhpF from Escherichia coli., Bieger B, Essen LO, J Mol Biol. 2001 Mar 16;307(1):1-8. PMID:11243797
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