1f48

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{{STRUCTURE_1f48| PDB=1f48 | SCENE= }}
{{STRUCTURE_1f48| PDB=1f48 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE'''
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===CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE===
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==Overview==
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Active extrusion is a common mechanism underlying detoxification of heavy metals, drugs and antibiotics in bacteria, protozoa and mammals. In Escherichia coli, the ArsAB pump provides resistance to arsenite and antimonite. This pump consists of a soluble ATPase (ArsA) and a membrane channel (ArsB). ArsA contains two nucleotide-binding sites (NBSs) and a binding site for arsenic or antimony. Binding of metalloids stimulates ATPase activity. The crystal structure of ArsA reveals that both NBSs and the metal-binding site are located at the interface between two homologous domains. A short stretch of residues connecting the metal-binding site to the NBSs provides a signal transduction pathway that conveys information on metal occupancy to the ATP hydrolysis sites. Based on these structural features, we propose that the metal-binding site is involved directly in the process of vectorial translocation of arsenite or antimonite across the membrane. The relative positions of the NBS and the inferred mechanism of allosteric activation of ArsA provide a useful model for the interaction of the catalytic domains in other transport ATPases.
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(as it appears on PubMed at http://www.pubmed.gov), where 10970874 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10970874}}
==About this Structure==
==About this Structure==
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[[Category: Atp binding site]]
[[Category: Atp binding site]]
[[Category: P-loop]]
[[Category: P-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:52:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:39:42 2008''

Revision as of 23:39, 30 June 2008

Image:1f48.png

Template:STRUCTURE 1f48

CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI ARSENITE-TRANSLOCATING ATPASE

Template:ABSTRACT PUBMED 10970874

About this Structure

1F48 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump., Zhou T, Radaev S, Rosen BP, Gatti DL, EMBO J. 2000 Sep 1;19(17):4838-45. PMID:10970874

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