This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1f5m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1f5m.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1f5m.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1f5m| PDB=1f5m | SCENE= }}
{{STRUCTURE_1f5m| PDB=1f5m | SCENE= }}
-
'''STRUCTURE OF THE GAF DOMAIN'''
+
===STRUCTURE OF THE GAF DOMAIN===
-
==Overview==
+
<!--
-
GAF domains are ubiquitous motifs present in cyclic GMP (cGMP)-regulated cyclic nucleotide phosphodiesterases, certain adenylyl cyclases, the bacterial transcription factor FhlA, and hundreds of other signaling and sensory proteins from all three kingdoms of life. The crystal structure of the Saccharomyces cerevisiae YKG9 protein was determined at 1.9 A resolution. The structure revealed a fold that resembles the PAS domain, another ubiquitous signaling and sensory transducer. YKG9 does not bind cGMP, but the isolated first GAF domain of phosphodiesterase 5 binds with K:(d) = 650 nM. The cGMP binding site of the phosphodiesterase GAF domain was identified by homology modeling and site-directed mutagenesis, and consists of conserved Arg, Asn, Lys and Asp residues. The structural and binding studies taken together show that the cGMP binding GAF domains form a new class of cyclic nucleotide receptors distinct from the regulatory domains of cyclic nucleotide-regulated protein kinases and ion channels.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11032796}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11032796 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11032796}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Cgmp binding]]
[[Category: Cgmp binding]]
[[Category: Gaf]]
[[Category: Gaf]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:55:48 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:44:08 2008''

Revision as of 23:44, 30 June 2008

Image:1f5m.png

Template:STRUCTURE 1f5m

STRUCTURE OF THE GAF DOMAIN

Template:ABSTRACT PUBMED 11032796

About this Structure

1F5M is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor., Ho YS, Burden LM, Hurley JH, EMBO J. 2000 Oct 16;19(20):5288-99. PMID:11032796

Page seeded by OCA on Tue Jul 1 02:44:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f5m"
Personal tools