1f6b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1f6b.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1f6b.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1f6b| PDB=1f6b | SCENE= }}
{{STRUCTURE_1f6b| PDB=1f6b | SCENE= }}
-
'''CRYSTAL STRUCTURE OF SAR1-GDP COMPLEX'''
+
===CRYSTAL STRUCTURE OF SAR1-GDP COMPLEX===
-
==Overview==
+
<!--
-
The Sar1 GTPase is an essential component of COPII vesicle coats involved in export of cargo from the ER. We report the 1.7-A structure of Sar1 and find that consistent with the sequence divergence of Sar1 from Arf family GTPases, Sar1 is structurally distinct. In particular, we show that the Sar1 NH2 terminus contains two regions: an NH2-terminal extension containing an evolutionary conserved hydrophobic motif that facilitates membrane recruitment and activation by the mammalian Sec12 guanine nucleotide exchange factor, and an alpha1' amphipathic helix that contributes to interaction with the Sec23/24 complex that is responsible for cargo selection during ER export. We propose that the hydrophobic Sar1 NH2-terminal activation/recruitment motif, in conjunction with the alpha1' helix, mediates the initial steps in COPII coat assembly for export from the ER.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11739406}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11739406 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11739406}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Mg-containing complex]]
[[Category: Mg-containing complex]]
[[Category: N-terminal helix]]
[[Category: N-terminal helix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:57:22 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:46:14 2008''

Revision as of 23:46, 30 June 2008

Image:1f6b.png

Template:STRUCTURE 1f6b

CRYSTAL STRUCTURE OF SAR1-GDP COMPLEX

Template:ABSTRACT PUBMED 11739406

About this Structure

1F6B is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export., Huang M, Weissman JT, Beraud-Dufour S, Luan P, Wang C, Chen W, Aridor M, Wilson IA, Balch WE, J Cell Biol. 2001 Dec 10;155(6):937-48. Epub 2001 Dec 10. PMID:11739406

Page seeded by OCA on Tue Jul 1 02:46:14 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f6b"
Personal tools