1f6f

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{{STRUCTURE_1f6f| PDB=1f6f | SCENE= }}
{{STRUCTURE_1f6f| PDB=1f6f | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR'''
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===CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR===
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==Overview==
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The structure of the ternary complex between ovine placental lactogen (oPL) and the extracellular domain (ECD) of the rat prolactin receptor (rPRLR) reveals that two rPRLR ECDs bind to opposite sides of oPL with pseudo two-fold symmetry. The two oPL receptor binding sites differ significantly in their topography and electrostatic character. These binding interfaces also involve different hydrogen bonding and hydrophobic packing patterns compared to the structurally related human growth hormone (hGH)-receptor complexes. Additionally, the receptor-receptor interactions are different from those of the hGH-receptor complex. The conformational adaptability of prolactin and growth hormone receptors is evidenced by the changes in local conformations of the receptor binding loops and more global changes induced by shifts in the angular relationships between the N- and C-terminal domains, which allow the receptor to bind to the two topographically distinct sites of oPL.
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The line below this paragraph, {{ABSTRACT_PUBMED_10966654}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10966654 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10966654}}
==About this Structure==
==About this Structure==
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[[Category: Fn iii domain]]
[[Category: Fn iii domain]]
[[Category: Ternary complex]]
[[Category: Ternary complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:57:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:46:41 2008''

Revision as of 23:46, 30 June 2008

Image:1f6f.png

Template:STRUCTURE 1f6f

CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR

Template:ABSTRACT PUBMED 10966654

About this Structure

1F6F is a Protein complex structure of sequences from Ovis aries and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor., Elkins PA, Christinger HW, Sandowski Y, Sakal E, Gertler A, de Vos AM, Kossiakoff AA, Nat Struct Biol. 2000 Sep;7(9):808-15. PMID:10966654

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