1f6m

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[[Image:1f6m.gif|left|200px]]
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{{Seed}}
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[[Image:1f6m.png|left|200px]]
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{{STRUCTURE_1f6m| PDB=1f6m | SCENE= }}
{{STRUCTURE_1f6m| PDB=1f6m | SCENE= }}
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'''CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THIOREDOXIN REDUCTASE, THIOREDOXIN, AND THE NADP+ ANALOG, AADP+'''
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===CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THIOREDOXIN REDUCTASE, THIOREDOXIN, AND THE NADP+ ANALOG, AADP+===
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==Overview==
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In thioredoxin reductase (TrxR) from Escherichia coli, cycles of reduction and reoxidation of the flavin adenine dinucleotide (FAD) cofactor depend on rate-limiting rearrangements of the FAD and NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) domains. We describe the structure of the flavin-reducing conformation of E. coli TrxR at a resolution of 3.0 angstroms. The orientation of the two domains permits reduction of FAD by NADPH and oxidation of the enzyme dithiol by the protein substrate, thioredoxin. The alternate conformation, described by Kuriyan and co-workers, permits internal transfer of reducing equivalents from reduced FAD to the active-site disulfide. Comparison of these structures demonstrates that switching between the two conformations involves a "ball-and-socket" motion in which the pyridine nucleotide-binding domain rotates by 67 degrees.
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The line below this paragraph, {{ABSTRACT_PUBMED_10947986}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10947986 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10947986}}
==About this Structure==
==About this Structure==
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[[Category: Redox-active center]]
[[Category: Redox-active center]]
[[Category: Ternary complex]]
[[Category: Ternary complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:57:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:47:01 2008''

Revision as of 23:47, 30 June 2008

Image:1f6m.png

Template:STRUCTURE 1f6m

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THIOREDOXIN REDUCTASE, THIOREDOXIN, AND THE NADP+ ANALOG, AADP+

Template:ABSTRACT PUBMED 10947986

About this Structure

1F6M is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Twists in catalysis: alternating conformations of Escherichia coli thioredoxin reductase., Lennon BW, Williams CH Jr, Ludwig ML, Science. 2000 Aug 18;289(5482):1190-4. PMID:10947986

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