1f75

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{{STRUCTURE_1f75| PDB=1f75 | SCENE= }}
{{STRUCTURE_1f75| PDB=1f75 | SCENE= }}
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'''CRYSTAL STRUCTURE OF UNDECAPRENYL DIPHOSPHATE SYNTHASE FROM MICROCOCCUS LUTEUS B-P 26'''
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===CRYSTAL STRUCTURE OF UNDECAPRENYL DIPHOSPHATE SYNTHASE FROM MICROCOCCUS LUTEUS B-P 26===
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==Overview==
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Undecaprenyl diphosphate synthase (UPS) catalyzes the cis-prenyl chain elongation onto trans, trans-farnesyl diphosphate (FPP) to produce undecaprenyl diphosphate (UPP), which is indispensable for the biosynthesis of bacterial cell walls. We report here the crystal structure of UPS as the only three-dimensional structure among cis-prenyl chain elongating enzymes. The structure is classified into a protein fold family and is completely different from the so-called "isoprenoid synthase fold" that is believed to be a common structure for the enzymes relating to isoprenoid biosynthesis. Conserved amino acid residues among cis-prenyl chain elongating enzymes are located around a large hydrophobic cleft in the UPS structure. A structural P-loop motif, which frequently appears in the various kinds of phosphate binding site, is found at the entrance of this cleft. The catalytic site is determined on the basis of these structural features, from which a possible reaction mechanism is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 11287651 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11287651}}
==About this Structure==
==About this Structure==
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[[Category: Parallel beta sheet]]
[[Category: Parallel beta sheet]]
[[Category: Peptidoglycan synthesis]]
[[Category: Peptidoglycan synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:59:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:48:36 2008''

Revision as of 23:48, 30 June 2008

Image:1f75.png

Template:STRUCTURE 1f75

CRYSTAL STRUCTURE OF UNDECAPRENYL DIPHOSPHATE SYNTHASE FROM MICROCOCCUS LUTEUS B-P 26

Template:ABSTRACT PUBMED 11287651

About this Structure

1F75 is a Single protein structure of sequence from Micrococcus luteus. Full crystallographic information is available from OCA.

Reference

Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase., Fujihashi M, Zhang YW, Higuchi Y, Li XY, Koyama T, Miki K, Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4337-42. Epub 2001 Apr 3. PMID:11287651

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