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1f7y

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[[Image:1f7y.gif|left|200px]]
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{{STRUCTURE_1f7y| PDB=1f7y | SCENE= }}
{{STRUCTURE_1f7y| PDB=1f7y | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF TWO UUCG LOOPS HIGHLIGHTS THE ROLE PLAYED BY 2'-HYDROXYL GROUPS IN ITS UNUSUAL STABILITY'''
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===THE CRYSTAL STRUCTURE OF TWO UUCG LOOPS HIGHLIGHTS THE ROLE PLAYED BY 2'-HYDROXYL GROUPS IN ITS UNUSUAL STABILITY===
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==Overview==
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All large structured RNAs contain hairpin motifs made of a stem closed by several looped nucleotides. The most frequent loop motif is the UUCG one. This motif belongs to the tetraloop family and has the peculiarity of being highly thermodynamically stable. Here, we report the first crystal structure of two UUCG tetraloops embedded in a larger RNA-protein complex solved at 2.8 A resolution. The two loops present in the asymmetric unit are in a different crystal packing environment but, nevertheless, have an identical conformation. The observed structure is globally close to that obtained in solution by nuclear magnetic resonance. However, subtle differences point to a more detailed picture of the role played by 2'-hydroxyl groups in stabilising this tetraloop.
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(as it appears on PubMed at http://www.pubmed.gov), where 11071808 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11071808}}
==About this Structure==
==About this Structure==
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[[Category: Uucg]]
[[Category: Uucg]]
[[Category: X-ray]]
[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:00:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:50:32 2008''

Revision as of 23:50, 30 June 2008

Image:1f7y.png

Template:STRUCTURE 1f7y

THE CRYSTAL STRUCTURE OF TWO UUCG LOOPS HIGHLIGHTS THE ROLE PLAYED BY 2'-HYDROXYL GROUPS IN ITS UNUSUAL STABILITY

Template:ABSTRACT PUBMED 11071808

About this Structure

1F7Y is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

The crystal structure of UUCG tetraloop., Ennifar E, Nikulin A, Tishchenko S, Serganov A, Nevskaya N, Garber M, Ehresmann B, Ehresmann C, Nikonov S, Dumas P, J Mol Biol. 2000 Nov 17;304(1):35-42. PMID:11071808

Page seeded by OCA on Tue Jul 1 02:50:32 2008

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