1f82

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{{STRUCTURE_1f82| PDB=1f82 | SCENE= }}
{{STRUCTURE_1f82| PDB=1f82 | SCENE= }}
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'''BOTULINUM NEUROTOXIN TYPE B CATALYTIC DOMAIN'''
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===BOTULINUM NEUROTOXIN TYPE B CATALYTIC DOMAIN===
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==Overview==
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Botulinum neurotoxin serotype B is a zinc protease that disrupts neurotransmitter release by cleaving synaptobrevin-II (Sb2), one of three SNARE proteins involved in neuronal synaptic vesicle fusion. The three-dimensional crystal structure of the apo botulinum neurotoxin serotype B catalytic domain (BoNT/B-LC) has been determined to 2.2 A resolution, and the complex of cleaved Sb2 with the catalytic domain (Sb2-BoNT/B-LC) has been determined to 2.0 A resolution. A comparison of the holotoxin catalytic domain and the isolated BoNT/B-LC structure shows a rearrangement of three active site loops. This rearrangement exposes the BoNT/B active site. The Sb2-BoNT/B-LC structure illustrates two distinct binding regions, which explains the specificity of each botulinum neurotoxin for its synaptic vesicle protein. This observation provides an explanation for the proposed cooperativity between binding of full-length substrate and catalysis and suggest a mechanism of synaptobrevin proteolysis employed by the clostridial neurotoxins.
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The line below this paragraph, {{ABSTRACT_PUBMED_10932255}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10932255 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10932255}}
==About this Structure==
==About this Structure==
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[[Category: Botulinum neurotoxin]]
[[Category: Botulinum neurotoxin]]
[[Category: Zinc dependent protease]]
[[Category: Zinc dependent protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:00:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:50:59 2008''

Revision as of 23:51, 30 June 2008

Image:1f82.png

Template:STRUCTURE 1f82

BOTULINUM NEUROTOXIN TYPE B CATALYTIC DOMAIN

Template:ABSTRACT PUBMED 10932255

About this Structure

1F82 is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution., Hanson MA, Stevens RC, Nat Struct Biol. 2000 Aug;7(8):687-92. PMID:10932255

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