1f85

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[[Image:1f85.gif|left|200px]]
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{{Seed}}
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[[Image:1f85.png|left|200px]]
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{{STRUCTURE_1f85| PDB=1f85 | SCENE= }}
{{STRUCTURE_1f85| PDB=1f85 | SCENE= }}
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'''SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE'''
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===SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE===
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==Overview==
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Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.
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The line below this paragraph, {{ABSTRACT_PUBMED_11101890}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11101890 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11101890}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F85 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F85 OCA].
==Reference==
==Reference==
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[[Category: Rna structure]]
[[Category: Rna structure]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:00:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:51:03 2008''

Revision as of 23:51, 30 June 2008

Image:1f85.png

Template:STRUCTURE 1f85

SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE

Template:ABSTRACT PUBMED 11101890

About this Structure

Full experimental information is available from OCA.

Reference

Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function., Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD, Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:11101890

Page seeded by OCA on Tue Jul 1 02:51:03 2008

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