1f9x

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{{STRUCTURE_1f9x| PDB=1f9x | SCENE= }}
{{STRUCTURE_1f9x| PDB=1f9x | SCENE= }}
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'''AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP'''
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===AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP===
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==Overview==
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The inhibitor of apoptosis proteins (IAPs) regulate the caspase family of cysteine proteases, which play an important role in the execution of programmed cell death. Human X-linked inhibitor of apoptosis protein (XIAP) is a potent inhibitor of caspases-3, -7, and -9. Here we show that the Bir3 domain is the minimal region of XIAP that is needed for potent caspase-9 inhibition. The three-dimensional structure of the Bir3 domain of XIAP, determined by NMR spectroscopy, resembles a classical zinc finger and consists of five alpha-helices, a three-stranded beta-sheet, and a zinc atom chelated to three cysteines and one histidine. The structure of the Bir3 domain is similar to that of the Bir2 domain of XIAP but differs from the previously determined structure of the Bir3 domain of MIHB. Based on site-directed mutagenesis, we have identified the regions of the Bir3 domain of XIAP that are important for inhibiting caspase-9. Despite the structural similarities of the Bir2 and Bir3 domain of XIAP, a different set of residues were found to be critical for inhibiting the individual caspases. These results suggest that XIAP inhibits caspase-3 and caspase-9 in a different manner.
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{{ABSTRACT_PUBMED_10934209}}
==About this Structure==
==About this Structure==
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1F9X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9X OCA].
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1F9X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F9X OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:05:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:56:09 2008''

Revision as of 23:56, 30 June 2008

Image:1f9x.png

Template:STRUCTURE 1f9x

AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP

Template:ABSTRACT PUBMED 10934209

About this Structure

1F9X is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP., Sun C, Cai M, Meadows RP, Xu N, Gunasekera AH, Herrmann J, Wu JC, Fesik SW, J Biol Chem. 2000 Oct 27;275(43):33777-81. PMID:10934209

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