1fa0

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{{STRUCTURE_1fa0| PDB=1fa0 | SCENE= }}
{{STRUCTURE_1fa0| PDB=1fa0 | SCENE= }}
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'''STRUCTURE OF YEAST POLY(A) POLYMERASE BOUND TO MANGANATE AND 3'-DATP'''
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===STRUCTURE OF YEAST POLY(A) POLYMERASE BOUND TO MANGANATE AND 3'-DATP===
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==Overview==
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Polyadenylate [poly(A)] polymerase (PAP) catalyzes the addition of a polyadenosine tail to almost all eukaryotic messenger RNAs (mRNAs). The crystal structure of the PAP from Saccharomyces cerevisiae (Pap1) has been solved to 2.6 angstroms, both alone and in complex with 3'-deoxyadenosine triphosphate (3'-dATP). Like other nucleic acid polymerases, Pap1 is composed of three domains that encircle the active site. The arrangement of these domains, however, is quite different from that seen in polymerases that use a template to select and position their incoming nucleotides. The first two domains are functionally analogous to polymerase palm and fingers domains. The third domain is attached to the fingers domain and is known to interact with the single-stranded RNA primer. In the nucleotide complex, two molecules of 3'-dATP are bound to Pap1. One occupies the position of the incoming base, prior to its addition to the mRNA chain. The other is believed to occupy the position of the 3' end of the mRNA primer.
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(as it appears on PubMed at http://www.pubmed.gov), where 10958780 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10958780}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotidyl transferase]]
[[Category: Nucleotidyl transferase]]
[[Category: Polymerase]]
[[Category: Polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:05:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:56:16 2008''

Revision as of 23:56, 30 June 2008

Image:1fa0.png

Template:STRUCTURE 1fa0

STRUCTURE OF YEAST POLY(A) POLYMERASE BOUND TO MANGANATE AND 3'-DATP

Template:ABSTRACT PUBMED 10958780

About this Structure

1FA0 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of yeast poly(A) polymerase alone and in complex with 3'-dATP., Bard J, Zhelkovsky AM, Helmling S, Earnest TN, Moore CL, Bohm A, Science. 2000 Aug 25;289(5483):1346-9. PMID:10958780

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