1fad

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{{STRUCTURE_1fad| PDB=1fad | SCENE= }}
{{STRUCTURE_1fad| PDB=1fad | SCENE= }}
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'''DEATH DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN PROTEIN, RESIDUES 89-183'''
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===DEATH DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN PROTEIN, RESIDUES 89-183===
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==Overview==
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A signal of Fas-mediated apoptosis is transferred through an adaptor protein Fas-associated death domain protein (FADD) by interactions between the death domains of Fas and FADD. To understand the signal transduction mechanism of Fas-mediated apoptosis, we solved the solution structure of a murine FADD death domain. It consists of six helices arranged in a similar fold to the other death domains. The interactions between the death domains of Fas and FADD analyzed by site-directed mutagenesis indicate that charged residues in helices alpha2 and alpha3 are involved in death domain interactions, and the interacting helices appear to interact in anti-parallel pattern, alpha2 of FADD with alpha3 of Fas and vice versa.
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The line below this paragraph, {{ABSTRACT_PUBMED_10347191}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10347191 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10347191}}
==About this Structure==
==About this Structure==
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1FAD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAD OCA].
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1FAD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAD OCA].
==Reference==
==Reference==
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[[Category: Death domain]]
[[Category: Death domain]]
[[Category: Fadd]]
[[Category: Fadd]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:05:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:57:08 2008''

Revision as of 23:57, 30 June 2008

Image:1fad.png

Template:STRUCTURE 1fad

DEATH DOMAIN OF FAS-ASSOCIATED DEATH DOMAIN PROTEIN, RESIDUES 89-183

Template:ABSTRACT PUBMED 10347191

About this Structure

1FAD is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD., Jeong EJ, Bang S, Lee TH, Park YI, Sim WS, Kim KS, J Biol Chem. 1999 Jun 4;274(23):16337-42. PMID:10347191

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