1fag

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[[Image:1fag.gif|left|200px]]
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{{STRUCTURE_1fag| PDB=1fag | SCENE= }}
{{STRUCTURE_1fag| PDB=1fag | SCENE= }}
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'''STRUCTURE OF CYTOCHROME P450'''
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===STRUCTURE OF CYTOCHROME P450===
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==Overview==
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The substrate-bound structures of two cytochrome P450s, P450cam and P450eryF, are known. While these structures reveal important features that control substrate specificity, the problem of how conformational changes allow for substrate entry and product release remains unsolved. The structure of the haem domain of the bacterial fatty acid hydroxylase, P450BM-3, previously was solved in the substrate-free form. Unlike the substrate-bound P450cam and P450eryF structures, the substrate access channel is open in substrate-free P450BM-3. Here we present the X-ray structure of P450BM-3 at 2.7 A bound with a fatty acid substrate, palmitoleic acid. A comparison of the substrate-bound and -free forms reveals major conformational differences and provides the first detailed picture of substrate-induced conformational changes in a P450.
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(as it appears on PubMed at http://www.pubmed.gov), where 9033595 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9033595}}
==About this Structure==
==About this Structure==
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[[Category: Heme]]
[[Category: Heme]]
[[Category: Monooxygenase]]
[[Category: Monooxygenase]]
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Revision as of 23:57, 30 June 2008

Image:1fag.png

Template:STRUCTURE 1fag

STRUCTURE OF CYTOCHROME P450

Template:ABSTRACT PUBMED 9033595

About this Structure

1FAG is a Single protein structure of sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid., Li H, Poulos TL, Nat Struct Biol. 1997 Feb;4(2):140-6. PMID:9033595

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