1fav

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fav.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1fav.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fav| PDB=1fav | SCENE= }}
{{STRUCTURE_1fav| PDB=1fav | SCENE= }}
-
'''THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE'''
+
===THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE===
-
==Overview==
+
<!--
-
The three-dimensional structure of the complex between an HIV-1 cell-entry inhibitor selected from screening a combinatorial library of non-natural building blocks and the central, trimeric, coiled-coil core of HIV-1 gp41 has been determined by X-ray crystallography. The biased combinatorial library was designed to identify ligands binding in nonpolar pockets on the surface of the coiled-coil core of gp41. The crystal structure shows that the non-peptide moiety of the inhibitor binds to the targeted cavity in two different binding modes. This result suggests a strategy for increasing inhibitor potency by use of a second-generation combinatorial library designed to give simultaneous occupancy of both binding sites.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11026535}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11026535 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11026535}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Hiv-1]]
[[Category: Hiv-1]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:06:56 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:58:20 2008''

Revision as of 23:58, 30 June 2008

Image:1fav.png

Template:STRUCTURE 1fav

THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE

Template:ABSTRACT PUBMED 11026535

About this Structure

1FAV is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core., Zhou G, Ferrer M, Chopra R, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Harrison SC, Wiley DC, Bioorg Med Chem. 2000 Sep;8(9):2219-27. PMID:11026535

Page seeded by OCA on Tue Jul 1 02:58:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fav"
Personal tools