1fc0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fc0.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1fc0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fc0| PDB=1fc0 | SCENE= }}
{{STRUCTURE_1fc0| PDB=1fc0 | SCENE= }}
-
'''HUMAN LIVER GLYCOGEN PHOSPHORYLASE COMPLEXED WITH N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE'''
+
===HUMAN LIVER GLYCOGEN PHOSPHORYLASE COMPLEXED WITH N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE===
-
==Overview==
+
<!--
-
Glycogen phosphorylases catalyze the breakdown of glycogen to glucose-1-phosphate, which enters glycolysis to fulfill the energetic requirements of the organism. Maintaining control of blood glucose levels is critical in minimizing the debilitating effects of diabetes, making liver glycogen phosphorylase a potential therapeutic target. To support inhibitor design, we determined the crystal structures of the active and inactive forms of human liver glycogen phosphorylase a. During activation, forty residues of the catalytic site undergo order/disorder transitions, changes in secondary structure, or packing to reorganize the catalytic site for substrate binding and catalysis. Knowing the inactive and active conformations of the liver enzyme and how each differs from its counterpart in muscle phosphorylase provides the basis for designing inhibitors that bind preferentially to the inactive conformation of the liver isozyme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10949035}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10949035 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10949035}}
==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Phosphorylated protein]]
[[Category: Phosphorylated protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:09:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:01:27 2008''

Revision as of 00:01, 1 July 2008

Image:1fc0.png

Template:STRUCTURE 1fc0

HUMAN LIVER GLYCOGEN PHOSPHORYLASE COMPLEXED WITH N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE

Template:ABSTRACT PUBMED 10949035

About this Structure

1FC0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core., Rath VL, Ammirati M, LeMotte PK, Fennell KF, Mansour MN, Danley DE, Hynes TR, Schulte GK, Wasilko DJ, Pandit J, Mol Cell. 2000 Jul;6(1):139-48. PMID:10949035

Page seeded by OCA on Tue Jul 1 03:01:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fc0"
Personal tools