1fcg

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[[Image:1fcg.gif|left|200px]]
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{{STRUCTURE_1fcg| PDB=1fcg | SCENE= }}
{{STRUCTURE_1fcg| PDB=1fcg | SCENE= }}
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'''ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA'''
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===ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA===
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==Overview==
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Fc gamma receptors bind IgG to initiate cellular responses against pathogens and soluble antigens. We have determined the three-dimensional structure of the extracellular portion of human Fc gammaRIIa to 2.0 A resolution providing a structural basis for the unique functions of the leukocyte FcR family. The receptor is composed of two immunoglobulin domains and arranged to expose the ligand-binding site at one end of domain 2. Using alanine mutants we find that the binding sites for IgG1 and 2 are similar but the relative importance of specific regions on the receptor varies. In crystals, Fc gammaRIIa molecules associate to resemble V(L)V(H) dimers, suggesting that two Fc gammaRIIa molecules could cooperate to bind IgG in an asymmetric manner.
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(as it appears on PubMed at http://www.pubmed.gov), where 10331870 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10331870}}
==About this Structure==
==About this Structure==
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[[Category: Immunogloulin]]
[[Category: Immunogloulin]]
[[Category: Leukocyte]]
[[Category: Leukocyte]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:10:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:02:42 2008''

Revision as of 00:02, 1 July 2008

Image:1fcg.png

Template:STRUCTURE 1fcg

ECTODOMAIN OF HUMAN FC GAMMA RECEPTOR, FCGRIIA

Template:ABSTRACT PUBMED 10331870

About this Structure

1FCG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa., Maxwell KF, Powell MS, Hulett MD, Barton PA, McKenzie IF, Garrett TP, Hogarth PM, Nat Struct Biol. 1999 May;6(5):437-42. PMID:10331870

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