1fcp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fcp.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1fcp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fcp| PDB=1fcp | SCENE= }}
{{STRUCTURE_1fcp| PDB=1fcp | SCENE= }}
-
'''FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI IN COMPLEX WITH BOUND FERRICHROME-IRON'''
+
===FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI IN COMPLEX WITH BOUND FERRICHROME-IRON===
-
==Overview==
+
<!--
-
FhuA, the receptor for ferrichrome-iron in Escherichia coli, is a member of a family of integral outer membrane proteins, which, together with the energy-transducing protein TonB, mediate the active transport of ferric siderophores across the outer membrane of Gram-negative bacteria. The three-dimensional structure of FhuA is presented here in two conformations: with and without ferrichrome-iron at resolutions of 2.7 and 2.5 angstroms, respectively. FhuA is a beta barrel composed of 22 antiparallel beta strands. In contrast to the typical trimeric arrangement found in porins, FhuA is monomeric. Located within the beta barrel is a structurally distinct domain, the "cork," which mainly consists of a four-stranded beta sheet and four short alpha helices. A single lipopolysaccharide molecule is noncovalently associated with the membrane-embedded region of the protein. Upon binding of ferrichrome-iron, conformational changes are transduced to the periplasmic pocket of FhuA, signaling the ligand-loaded status of the receptor. Sequence homologies and mutagenesis data are used to propose a structural mechanism for TonB-dependent siderophore-mediated transport across the outer membrane.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9856937}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9856937 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9856937}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Iron transport protein]]
[[Category: Iron transport protein]]
[[Category: Tonb-dependent receptor]]
[[Category: Tonb-dependent receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:10:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:03:28 2008''

Revision as of 00:03, 1 July 2008

Image:1fcp.png

Template:STRUCTURE 1fcp

FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI IN COMPLEX WITH BOUND FERRICHROME-IRON

Template:ABSTRACT PUBMED 9856937

About this Structure

1FCP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide., Ferguson AD, Hofmann E, Coulton JW, Diederichs K, Welte W, Science. 1998 Dec 18;282(5397):2215-20. PMID:9856937

Page seeded by OCA on Tue Jul 1 03:03:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fcp"
Personal tools