1ffx

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[[Image:1ffx.gif|left|200px]]
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{{Seed}}
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[[Image:1ffx.png|left|200px]]
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{{STRUCTURE_1ffx| PDB=1ffx | SCENE= }}
{{STRUCTURE_1ffx| PDB=1ffx | SCENE= }}
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'''TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX'''
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===TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX===
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==Overview==
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Phosphoproteins of the stathmin family interact with the alphabeta tubulin heterodimer (tubulin) and hence interfere with microtubule dynamics. The structure of the complex of GDP-tubulin with the stathmin-like domain of the neural protein RB3 reveals a head-to-tail assembly of two tubulins with a 91-residue RB3 alpha helix in which each copy of an internal duplicated sequence interacts with a different tubulin. As a result of the relative orientations adopted by tubulins and by their alpha and beta subunits, the tubulin:RB3 complex forms a curved structure. The RB3 helix thus most likely prevents incorporation of tubulin into microtubules by holding it in an assembly with a curvature very similar to that of the depolymerization products of microtubules.
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The line below this paragraph, {{ABSTRACT_PUBMED_11030624}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11030624 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11030624}}
==About this Structure==
==About this Structure==
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[[Category: Stathmin]]
[[Category: Stathmin]]
[[Category: Tubulin]]
[[Category: Tubulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:16:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:11:18 2008''

Revision as of 00:11, 1 July 2008

Image:1ffx.png

Template:STRUCTURE 1ffx

TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX

Template:ABSTRACT PUBMED 11030624

About this Structure

1FFX is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The 4 A X-ray structure of a tubulin:stathmin-like domain complex., Gigant B, Curmi PA, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, Cell. 2000 Sep 15;102(6):809-16. PMID:11030624

Page seeded by OCA on Tue Jul 1 03:11:18 2008

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