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1ffz

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[[Image:1ffz.gif|left|200px]]
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{{STRUCTURE_1ffz| PDB=1ffz | SCENE= }}
{{STRUCTURE_1ffz| PDB=1ffz | SCENE= }}
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'''LARGE RIBOSOMAL SUBUNIT COMPLEXED WITH R(CC)-DA-PUROMYCIN'''
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===LARGE RIBOSOMAL SUBUNIT COMPLEXED WITH R(CC)-DA-PUROMYCIN===
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==Overview==
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Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and address the catalytic properties of its all-RNA active site. Both substrate analogs are contacted exclusively by conserved ribosomal RNA (rRNA) residues from domain V of 23S rRNA; there are no protein side-chain atoms closer than about 18 angstroms to the peptide bond being synthesized. The mechanism of peptide bond synthesis appears to resemble the reverse of the acylation step in serine proteases, with the base of A2486 (A2451 in Escherichia coli) playing the same general base role as histidine-57 in chymotrypsin. The unusual pK(a) (where K(a) is the acid dissociation constant) required for A2486 to perform this function may derive in part from its hydrogen bonding to G2482 (G2447 in E. coli), which also interacts with a buried phosphate that could stabilize unusual tautomers of these two bases. The polypeptide exit tunnel is largely formed by RNA but has significant contributions from proteins L4, L22, and L39e, and its exit is encircled by proteins L19, L22, L23, L24, L29, and L31e.
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The line below this paragraph, {{ABSTRACT_PUBMED_10937990}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10937990 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10937990}}
==About this Structure==
==About this Structure==
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[[Category: Ribozyme]]
[[Category: Ribozyme]]
[[Category: Rna-rna complex]]
[[Category: Rna-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:16:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:11:26 2008''

Revision as of 00:11, 1 July 2008

Image:1ffz.png

Template:STRUCTURE 1ffz

LARGE RIBOSOMAL SUBUNIT COMPLEXED WITH R(CC)-DA-PUROMYCIN

Template:ABSTRACT PUBMED 10937990

About this Structure

1FFZ is a Single protein structure of sequence from Haloarcula marismortui. Full crystallographic information is available from OCA.

Reference

The structural basis of ribosome activity in peptide bond synthesis., Nissen P, Hansen J, Ban N, Moore PB, Steitz TA, Science. 2000 Aug 11;289(5481):920-30. PMID:10937990

Page seeded by OCA on Tue Jul 1 03:11:26 2008

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