1fg2

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{{STRUCTURE_1fg2| PDB=1fg2 | SCENE= }}
{{STRUCTURE_1fg2| PDB=1fg2 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP33 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB'''
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===CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP33 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB===
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==Overview==
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Viral escape, first characterized for the lymphocytic choriomeningitis virus (LCMV) in a mouse transgenic for the P14 T cell-receptor (TCR), can be due to mutations in T-cell epitopes. We have measured the affinity between the H-2D(b) containing the wild-type and two of its "viral escape" epitopes, as well as other altered peptide ligands (APL), by using BIACORE analysis, and solved the crystal structure of H-2D(b) in complex with the wild-type peptide at 2.75 A resolution. We show that viral escape is due to a 50 to 100-fold reduction in the level of affinity between the P14 TCR and the binary complexes of the MHC molecule with the different peptides. Structurally, one of the mutations alters a TCR contact residue, while the effect of the other on the binding of the TCR must be indirect through structural rearrangements. The former is a null ligand, while the latter still leads to some central tolerance. This work defines the structural and energetic threshold for viral escape.
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(as it appears on PubMed at http://www.pubmed.gov), where 10993729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10993729}}
==About this Structure==
==About this Structure==
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[[Category: Tissot, A C.]]
[[Category: Tissot, A C.]]
[[Category: Ig fold]]
[[Category: Ig fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:16:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:11:40 2008''

Revision as of 00:11, 1 July 2008

Image:1fg2.png

Template:STRUCTURE 1fg2

CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP33 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB

Template:ABSTRACT PUBMED 10993729

About this Structure

1FG2 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex., Tissot AC, Ciatto C, Mittl PR, Grutter MG, Pluckthun A, J Mol Biol. 2000 Sep 29;302(4):873-85. PMID:10993729

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