1fgk

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{{STRUCTURE_1fgk| PDB=1fgk | SCENE= }}
{{STRUCTURE_1fgk| PDB=1fgk | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1'''
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===CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1===
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==Overview==
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The crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FGFR1K) has been determined in its unliganded form to 2.0 angstroms resolution and in complex with with an ATP analog to 2.3 angstrosms A resolution. Several features distinguish the structure of FGFR1K from that of the tyrosine kinase domain of the insulin receptor. Residues in the activation loop of FGFR1K appear to interfere with substrate peptide binding but not with ATP binding, revealing a second and perhaps more general autoinhibitory mechanism for receptor tyrosine kinases. In addition, a dimeric form of FGFR1K observed in the crystal structure may provide insights into the molecular mechanisms by which FGF receptors are activated. Finally, the structure provides a basis for rationalizing the effects of kinase mutations in FGF receptors that lead to developmental disorders in nematodes and humans.
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The line below this paragraph, {{ABSTRACT_PUBMED_8752212}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8752212 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8752212}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:18:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:12:57 2008''

Revision as of 00:12, 1 July 2008

Image:1fgk.png

Template:STRUCTURE 1fgk

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1

Template:ABSTRACT PUBMED 8752212

About this Structure

1FGK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism., Mohammadi M, Schlessinger J, Hubbard SR, Cell. 1996 Aug 23;86(4):577-87. PMID:8752212

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