1fh0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fh0.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1fh0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fh0| PDB=1fh0 | SCENE= }}
{{STRUCTURE_1fh0| PDB=1fh0 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR'''
+
===CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR===
-
==Overview==
+
<!--
-
Cathepsin V is a lysosomal cysteine protease that is expressed in the thymus, testis and corneal epithelium. We have determined the 1.6 A resolution crystal structure of human cathepsin V associated with an irreversible vinyl sulfone inhibitor. The fold of this enzyme is similar to the fold adopted by other members of the papain superfamily of cysteine proteases. This study provides a framework for understanding the structural basis for cathepsin V's activity and will aid in the design of inhibitors of this enzyme. A comparison of cathepsin V's active site with the active sites of related proteases revealed a number of differences, especially in the S2 and S3 subsites, that could be exploited in identifying specific cathepsin V inhibitors or in identifying inhibitors of other cysteine proteases that would be selective against cathepsin V.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11027133}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11027133 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11027133}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Papain]]
[[Category: Papain]]
[[Category: Protease]]
[[Category: Protease]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:18:52 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:14:10 2008''

Revision as of 00:14, 1 July 2008

Image:1fh0.png

Template:STRUCTURE 1fh0

CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR

Template:ABSTRACT PUBMED 11027133

About this Structure

1FH0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cathepsin V., Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME, Biochemistry. 2000 Oct 17;39(41):12543-51. PMID:11027133

Page seeded by OCA on Tue Jul 1 03:14:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fh0"
Personal tools