1fhz

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[[Image:1fhz.gif|left|200px]]
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{{Seed}}
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[[Image:1fhz.png|left|200px]]
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{{STRUCTURE_1fhz| PDB=1fhz | SCENE= }}
{{STRUCTURE_1fhz| PDB=1fhz | SCENE= }}
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'''PSORALEN CROSS-LINKED D(CCGGTACCGG) FORMS HOLLIDAY JUNCTION'''
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===PSORALEN CROSS-LINKED D(CCGGTACCGG) FORMS HOLLIDAY JUNCTION===
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==Overview==
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The single-crystal structures are presented for two DNA sequences with the thymine bases covalently cross-linked across the complementary strands by 4'-hydroxymethyl-4,5',8-trimethylpsoralen (HMT). The HMT-adduct of d(CCGCTAGCGG) forms a psoralen-induced Holliday junction, showing for the first time the effect of this important class of chemotheraputics on the structure of the recombination intermediate. In contrast, HMT-d(CCGGTACCGG) forms a sequence-dependent junction. In both structures, the DNA duplex is highly distorted at the thymine base linked to the six-member pyrone ring of the drug. The psoralen cross-link defines the intramolecular interactions of the drug-induced junction, while the sequence-dependent structure is nearly identical to the native Holliday junction of d(CCGGTACCGG) alone. The two structures contrast the effects of drug- and sequence-dependent interactions on the structure of a Holliday junction, suggesting a role for psoralen in the mechanism to initiate repair of psoralen-lesions in mammalian DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_11302703}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11302703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11302703}}
==About this Structure==
==About this Structure==
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[[Category: Holliday junction]]
[[Category: Holliday junction]]
[[Category: Psoralen]]
[[Category: Psoralen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:20:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:16:29 2008''

Revision as of 00:16, 1 July 2008

Image:1fhz.png

Template:STRUCTURE 1fhz

PSORALEN CROSS-LINKED D(CCGGTACCGG) FORMS HOLLIDAY JUNCTION

Template:ABSTRACT PUBMED 11302703

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions., Eichman BF, Mooers BH, Alberti M, Hearst JE, Ho PS, J Mol Biol. 2001 Apr 20;308(1):15-26. PMID:11302703

Page seeded by OCA on Tue Jul 1 03:16:29 2008

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