1fi7

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{{STRUCTURE_1fi7| PDB=1fi7 | SCENE= }}
{{STRUCTURE_1fi7| PDB=1fi7 | SCENE= }}
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'''Solution structure of the imidazole complex of cytochrome C'''
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===Solution structure of the imidazole complex of cytochrome C===
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==Overview==
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Although imidazole ligand binding to cytochrome c is not directly related to its physiological function, it has the potential to provide valuable information on the molecular and electronic structure of the protein. The solution structure of the imidazole adduct of oxidized horse heart cytochrome c (Im-cyt c) has been determined through 2D NMR spectroscopy. The Im-cyt c, 8 mM in 1.2 M imidazole solution at pH 5.7 and 313 K, provided altogether 2,542 NOEs (1,901 meaningful NOEs) and 194 pseudocontact shifts. The 35 conformers of the family show the RMSD values to the average structure of 0.063+/-0.007 nm for the backbone and 0.107+/-0.007 nm for all heavy atoms, respectively. The characterization of Im-cyt c is discussed in detail both in terms of structure and electronic properties. The replacement of the axial ligand Met80 with the exogenous imidazole ligand induces significant conformation changes in both backbone and side chains of the residues located in the distal axial ligand regions. The imidazole ligand binds essentially parallel to the imidazole of the proximal histidine, the two planes forming an angle of 8+/-7 degrees. The electron delocalization on the heme moiety and the magnetic susceptibility tensor are consistent with these structural features.
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(as it appears on PubMed at http://www.pubmed.gov), where 11472026 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11472026}}
==About this Structure==
==About this Structure==
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1FI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FI7 OCA].
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1FI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FI7 OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Solution structure]]
[[Category: Solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:21:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:17:14 2008''

Revision as of 00:17, 1 July 2008

Image:1fi7.png

Template:STRUCTURE 1fi7

Solution structure of the imidazole complex of cytochrome C

Template:ABSTRACT PUBMED 11472026

About this Structure

1FI7 is a Single protein structure of sequence from Equus caballus. Full experimental information is available from OCA.

Reference

Effects of extrinsic imidazole ligation on the molecular and electronic structure of cytochrome c., Banci L, Bertini I, Liu G, Lu J, Reddig T, Tang W, Wu Y, Yao Y, Zhu D, J Biol Inorg Chem. 2001 Jun;6(5-6):628-37. PMID:11472026

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