1fi8

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[[Image:1fi8.gif|left|200px]]
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{{Seed}}
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[[Image:1fi8.png|left|200px]]
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{{STRUCTURE_1fi8| PDB=1fi8 | SCENE= }}
{{STRUCTURE_1fi8| PDB=1fi8 | SCENE= }}
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'''RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]'''
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===RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]===
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==Overview==
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Granzyme B is a serine protease of the chymotrypsin fold that mediates cell death by cytotoxic lymphocytes. It is a processing enzyme, requiring extended peptide substrates containing an Asp residue. The determinants that allow for this substrate specificity are revealed in the three-dimensional structure of granzyme B in complex with a macromolecular inhibitor. The primary specificity for Asp occurs through a side-on interaction with Arg 226, a buried Arg side chain of granzyme B. An additional nine amino acids make contact with the substrate and define the granzyme B extended substrate specificity profile. The substrate determinants found in this structure are shared by other members of this protein class and help to reveal the properties that define substrate specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_10966646}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10966646 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10966646}}
==About this Structure==
==About this Structure==
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[[Category: Granzyme b]]
[[Category: Granzyme b]]
[[Category: Protease substrate interaction]]
[[Category: Protease substrate interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:21:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:17:16 2008''

Revision as of 00:17, 1 July 2008

Image:1fi8.png

Template:STRUCTURE 1fi8

RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]

Template:ABSTRACT PUBMED 10966646

About this Structure

1FI8 is a Protein complex structure of sequences from Escherichia coli and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity., Waugh SM, Harris JL, Fletterick R, Craik CS, Nat Struct Biol. 2000 Sep;7(9):762-5. PMID:10966646

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