1fie

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[[Image:1fie.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1fie| PDB=1fie | SCENE= }}
{{STRUCTURE_1fie| PDB=1fie | SCENE= }}
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'''RECOMBINANT HUMAN COAGULATION FACTOR XIII'''
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===RECOMBINANT HUMAN COAGULATION FACTOR XIII===
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==Overview==
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The three-dimensional structure of the recombinant human factor XIII a2 dimer after cleavage by thrombin has been determined by X-ray crystallography. Factor XIII zymogen was treated with bovine alpha-thrombin in the presence of 3 mM CaCl2, and the cleaved protein was crystallized from Tris buffered at pH 6.5 using ethanol as the precipitating agent. Refinement of the molecular model of thrombin-cleaved factor XIII against diffraction data from 10.0 to 2.5 A resolution has been carried out to give a crystallographic R factor of 18.2%. The structure of thrombin-cleaved factor XIII is remarkably similar to that of the zymogen: there are no large conformational changes in the protein and the 37 residue amino terminus activation peptide remains associated with the rest of the molecule. This work shows that the activation peptide, upon thrombin cleavage, has the same conformation and occupies the same position with respect to the rest of the molecule as it does in the zymogen structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_7660355}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7660355 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7660355}}
==About this Structure==
==About this Structure==
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[[Category: Blood coagulation]]
[[Category: Blood coagulation]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:21:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:19:08 2008''

Revision as of 00:19, 1 July 2008

Image:1fie.png

Template:STRUCTURE 1fie

RECOMBINANT HUMAN COAGULATION FACTOR XIII

Template:ABSTRACT PUBMED 7660355

About this Structure

1FIE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII., Yee VC, Pedersen LC, Bishop PD, Stenkamp RE, Teller DC, Thromb Res. 1995 Jun 1;78(5):389-97. PMID:7660355

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