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1fim

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{{STRUCTURE_1fim| PDB=1fim | SCENE= }}
{{STRUCTURE_1fim| PDB=1fim | SCENE= }}
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'''MACROPHAGE MIGRATION INHIBITORY FACTOR'''
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===MACROPHAGE MIGRATION INHIBITORY FACTOR===
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==Overview==
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The tertiary structure of the macrophage migration inhibitory factor (MIF) from rat liver (12,300 Mr) is presented at 2.2 A resolution. Each monomer consists of two beta/alpha/beta motifs aligned in quasi two-fold symmetry, comprising a domain consisting of a four-stranded mixed beta-sheet and two antiparallel alpha-helices. The protein exists as a trimer in the crystal. An extra beta-strand that is almost perpendicular to the other beta-strands joins to the beta-sheet of the neighbouring monomer in the trimer. Unexpected similarities were detected between MIF and two kinds of isomerase.
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The line below this paragraph, {{ABSTRACT_PUBMED_8605628}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8605628 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8605628}}
==About this Structure==
==About this Structure==
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[[Category: Inflammatory response]]
[[Category: Inflammatory response]]
[[Category: Macrophage]]
[[Category: Macrophage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:22:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:19:38 2008''

Revision as of 00:19, 1 July 2008

Image:1fim.png

Template:STRUCTURE 1fim

MACROPHAGE MIGRATION INHIBITORY FACTOR

Template:ABSTRACT PUBMED 8605628

About this Structure

1FIM is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the macrophage migration inhibitory factor from rat liver., Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Nishihira J, Sakai M, Nat Struct Biol. 1996 Mar;3(3):259-66. PMID:8605628

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