1fl3

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{{STRUCTURE_1fl3| PDB=1fl3 | SCENE= }}
{{STRUCTURE_1fl3| PDB=1fl3 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K'''
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===CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K===
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==Overview==
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The forte of catalytic antibodies has resided in the control of the ground-state reaction coordinate. A principle and method are now described in which antibodies can direct the outcome of photophysical and photochemical events that take place on excited-state potential energy surfaces. The key component is a chemically reactive optical sensor that provides a direct report of the dynamic interplay between protein and ligand at the active site. To illustrate the concept, we used a trans-stilbene hapten to elicit a panel of monoclonal antibodies that displayed a range of fluorescent spectral behavior when bound to a trans-stilbene substrate. Several antibodies yielded a blue fluorescence indicative of an excited-state complex or "exciplex" between trans-stilbene and the antibody. The antibodies controlled the isomerization coordinate of trans-stilbene and dynamically coupled this manifold with an active-site residue. A step was taken toward the use of antibody-based photochemical sensors for diagnostic and clinical applications.
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The line below this paragraph, {{ABSTRACT_PUBMED_11030644}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11030644 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11030644}}
==About this Structure==
==About this Structure==
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[[Category: Stevens, R C.]]
[[Category: Stevens, R C.]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:27:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:25:44 2008''

Revision as of 00:25, 1 July 2008

Image:1fl3.png

Template:STRUCTURE 1fl3

CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K

Template:ABSTRACT PUBMED 11030644

About this Structure

Full crystallographic information is available from OCA.

Reference

Blue-fluorescent antibodies., Simeonov A, Matsushita M, Juban EA, Thompson EH, Hoffman TZ, Beuscher AE 4th, Taylor MJ, Wirsching P, Rettig W, McCusker JK, Stevens RC, Millar DP, Schultz PG, Lerner RA, Janda KD, Science. 2000 Oct 13;290(5490):307-13. PMID:11030644

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