1fli

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{{STRUCTURE_1fli| PDB=1fli | SCENE= }}
{{STRUCTURE_1fli| PDB=1fli | SCENE= }}
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'''DNA-BINDING DOMAIN OF FLI-1'''
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===DNA-BINDING DOMAIN OF FLI-1===
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==Overview==
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Members of the ets family of transcription factors share a conserved DNA-binding domain, the ets domain. By using multidimensional NMR, we have determined the structure of the ets domain of human Fli-1 in the DNA-bound form. It consists of three alpha-helices and a four-stranded beta-sheet, similar to structures of the class of helix-turn-helix DNA binding proteins first found in the catabolite activator protein of Escherichia coli. NMR and mutagenesis experiments suggest that in comparison to structurally related proteins, the ets domain uses a new variation of the helix-turn-helix motif for binding to DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 7773776 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7773776}}
==About this Structure==
==About this Structure==
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1FLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA].
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1FLI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLI OCA].
==Reference==
==Reference==
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[[Category: Yu, L.]]
[[Category: Yu, L.]]
[[Category: Transcription/dna]]
[[Category: Transcription/dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:28:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:26:34 2008''

Revision as of 00:26, 1 July 2008

Image:1fli.png

Template:STRUCTURE 1fli

DNA-BINDING DOMAIN OF FLI-1

Template:ABSTRACT PUBMED 7773776

About this Structure

1FLI is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the ets domain of Fli-1 when bound to DNA., Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW, Nat Struct Biol. 1994 Dec;1(12):871-5. PMID:7773776

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